Journal article
Synthesis of Thermoresponsive, Catechol-Rich Poly(ethylene glycol) Brush Polymers for Attenuating Cellular Oxidative Stress
Francesca Ercole, Chan-Jin Kim, Nam V Dao, Warren KL Tse, Michael R Whittaker, Frank Caruso, John F Quinn
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2023
Abstract
Herein, we report a platform to integrate customizable quantities of catechol units into polymers by reacting caffeic acid carbonic anhydride with polymers having pendant amine groups. Brush poly(ethylene glycol)-caffeamide (PEG-CAF) copolymers based on oligo(ethylene glycol)methyl ether methacrylate (OEGMA500) were obtained with a catechol content of approximately 30, 40, and 50 mol % (vs OEGMA content). Owing to the hydrophobicity of the introduced CAF groups, the catechol copolymers exhibited cloud points in the range of 23-46 °C and were used to fabricate thermoresponsive FeIII metal-phenolic network capsules. Polymers with the highest CAF content (50 mol %) proved most effective for att..
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Grants
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council Senior Principal Research Fellowship
Awarded by ARC
Funding Acknowledgements
This research was funded by the Australian Research Council through the Discovery Project (DP200100713) scheme. F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806) . J.F.Q. acknowledges the receipt of a Future Fellowship (FT170100144) from the ARC. This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF) .